Ep 206  |  Anna Lembke

How We’ve ‘Drugified’ Our Entire Existence: Dopamine & Addiction In the Digital Age

Check out this podcast

The Great Simplification

Description

Dopamine: the most famous neurotransmitter that regulates pleasure, motivation, and (perhaps most importantly) addiction. When examining  why our society is hooked on consuming more and more of everything – food, clothes, videos, news, vacations – it’s imperative to look at how our modern environments hijack our brain’s dopamine, sending it into overdrive at nearly every turn. Could taking a closer look at how our societal norms make us more vulnerable to addiction help us transition to more balanced and mindful lifestyles?

In this episode, Nate is joined by New York Times bestselling author and professor of psychiatry,  Anna Lembke, to explore how modern society has “drugified” our lived experience through digital media, processed foods, and instant gratification, resulting in an environment that propagates addiction. She explains how dopamine works as our brain’s reward signal and why our ancient wiring is mismatched for today’s level of high-dopamine stimuli in everyday life – leading to tolerance, withdrawal, and even anhedonia. Ultimately, Anna emphasizes that addiction is not a personal failing but a predictable response to an environment designed to take advantage of our brain’s neurochemistry.

What are the key practices individuals can use to reduce their addictive tendencies, even as our culture continues to prioritize quick dopamine hits and consumption? How long does it take to see the positive effects after moving away from the stimulus related to our addictive behavior? Lastly, if we acknowledge that information alone isn’t enough, what cultural shifts can we make to foster more connection, digital mindfulness, and authenticity, in order to return to a slower, lower throughput way of living?

About Anna Lembke

Anna Lembke is professor of psychiatry at Stanford University School of Medicine and chief of the Stanford Addiction Medicine Dual Diagnosis Clinic. As a clinician scholar, she has published more than a hundred peer-reviewed papers, book chapters, and commentaries. She sits on the board of several state and national addiction-focused organizations, has testified before various committees in the United States House of Representatives and Senate, and maintains a thriving clinical practice.

In 2016, she published Drug Dealer, MD – How Doctors Were Duped, Patients Got Hooked, and Why It’s So Hard to Stop, which was highlighted in the New York Times as one of the top five books to read to understand the opioid epidemic. Dr. Lembke also appeared on the Netflix documentary The Social Dilemma, an unvarnished look at the impact of social media on our lives. 

Her most recent book, Dopamine Nation: Finding Balance in the Age of Indulgence, explores how to moderate compulsive overconsumption in a dopamine-overloaded world and is a New York Times Bestseller.

In French, we have a motto that says that a simple drawing is often better than a long explanation. Jean-Marc Jancovici Carbone 4 President

That’s very understandable because with left atmosphere thinking, one of the problems is that you see everything as a series of problems that must have solutions. Iain McGilchrist Neuroscientist and Philosopher

We can’t have hundreds and hundreds of real relationships that are healthy because that requires time and effort and full attention and awareness of being in real relationship and conversation with the other human. Nate Hagens Director of ISEOF

This is the crux of the whole problem. Individual parts of nature are more valuable than the biocomplexity of nature. Thomas Crowther Founder Restor

Show Notes & Links to Learn More

Download transcript

The TGS team puts together these brief references and show notes for the learning and convenience of our listeners. However, most of the points made in episodes hold more nuance than one link can address, and we encourage you to dig deeper into any of these topics and come to your own informed conclusions.

00:00 – Anna Lembke: Bio + Works

05:05 – Digital media, drugs, and alcohol trigger same reward pathways in the brain

06:58 – Wolfram Schultz, paper on rewards and dopamine neurons in monkeys

07:09 – Peter Whybrow – American Mania: When More is Not Enough, TGS Episode

10:57 – Dopamine, serotonin, oxytocin, norepinephrine 

12:16 – Experiment: probe in nucleus accumbens in rat brain measures dopamine firing increase in response to chocolate (55%), sex (100%), nicotine (150%), cocaine (200%), amphetamine (1000%)

15:30 – Dopamine addiction and fasting

23:10 – Phenomenology, phenomenological approach to addiction

23:24 – Addiction is a spectrum

25:10 – 10-15% U.S. alcohol use disorder prevalence, ~10% U.S. drug use disorder prevalence

29:02 – Factors that increase risk of addiction

31:25 – The Great Simplification movie

32:27 – Heads of AI labs publicly warning that these models might cause human extinction, Geoffrey Hinton (“Godfather of AI”) warnings about ASI

32:42 – The Social Dilemma, Tristan Harris + TGS Episode

36:06 – Jonathan Haidt, Jonathan Haidt on TGS

36:25 – Porn addiction and impact on real-life relationships

37:20 – Anhedonia

38:48 – DSM-5 Diagnostic Criteria: Substance Use Disorder

46:57 – How long does detox take?, Protracted abstinence, Neuroplasticity

47:56 – Nora Volkow on methamphetamine addiction and dopamine transmission

48:30 – Addiction and genetics, Family and twin studies regarding lived environment and genetic factors in addiction

55:03 – Adolescence and addiction, Seniors and addiction

56:17 – Neuroplasticity as we age

56:38 – Frankly #112: The Quadruple Bifurcation

1:03:11 – Carbon pulse

1:03:56 – In the U.S. more people are living alone than ever before

1:04:39 – Isolation in retirement communities

1:06:22 – Derealization, depersonalization

1:18:13 – Radical honesty, Anna Lembke video on radical honesty and addition

1:21:30 – Most adults tell 1-2 lies per day

1:24:05 – Anna Lembke on Diary of a CEO

1:27:15 – Internet and Technology Addicts Anonymous

1:27:44 – GLP-1s and dopamine, Opioid antagonists (receptor blockers)

1:29:24 – Audrey Tang + TGS Episode

Back to episodes
End of Year ReflectionsWith Nate HagensThe Great SimplificationEp 205 | Nate Hagens

In this week’s episode, Nate reflects on four years(!) of the podcast by answering listener-submitted questions, which cover a broad range of topics related to The Great Simplification. He invites subscribers to investigate how they navigate a complex and ever-changing world, while avoiding overly prescriptive solutions that brush aside personal agency and the inherent uncertainty that exists in our world.

Watch nowDec 17, 2025
Fighting for a Livable FutureWith Kelly ErhartThe Great SimplificationEp 204 | Kelly Erhart

While current conversations about global heating tend to center around a few well-established pieces of science, we don’t often hear about the scientists and leaders working at the frontier of what is still unknown about Earth’s systems. This includes unpredictable tipping points and cascading effects of our rapidly changing climate, as well as the unconventional adaptation strategies that might help us maintain a stable planet. What is the newest climate science being researched right now, and what areas are we still needing to explore as we fight for a livable future? 

Watch nowDec 10, 2025
If Anyone Builds It, Everyone DiesWith Nate SoaresThe Great SimplificationEp 203 | Nate Soares

Technological development has always been a double-edged sword for humanity: the printing press increased the spread of misinformation, cars disrupted the fabric of our cities, and social media has made us increasingly polarized and lonely. But it has not been since the invention of the nuclear bomb that technology has presented such a severe existential risk to humanity – until now, with the possibility of Artificial Super Intelligence (ASI) on the horizon. Were ASI to come to fruition, it would be so powerful that it would outcompete human beings in everything – from scientific discovery to strategic warfare. What might happen to our species if we reach this point of singularity, and how can we steer away from the worst outcomes?

Watch nowDec 3, 2025

Subscribe to our Substack

The Institute for the Study of Energy and Our Future (ISEOF) is a 501(c)(3) non-profit corporation, founded in 2008, that conducts research and educates the public about energy issues and their impact on society.

Support our work
Get in touch
x